The Score in the "Search" form and Score in the "Protein" tab shows the confidence of the chemical-protein interactions that is defined by the STITCH database. STITCH utilized a Bayesian scoring scheme to calculate a combined score from different sources of experiment, database and text-mining. The highest and lowest scores are 1 and 0.

Table 1. The level and corresponding threshold for selecting chemical-protein interactions for inference.

• Default level used to extract chemical-protein interactions is "Low" (Score: 0.15) that all interactions will be utilized for inference.
• Users can change the level to "Medium" or "High" that fewer interaction will be included for analysis, while high-confident interactions might provide more reliable estimation of disease inference.
• For poorly characterized chemicals with only a few available interactions, it is suggested to use the default "Low" level due to the limited information available for inference.
• For relatively well-studied chemicals, level "High" is suggested for examination of more reliable inferences and generate hypothesis that is more likely to be validated experimentally, while level "Low" may be used to explore novel hypothesis for further study.